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KMID : 0369820040340060477
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Jorunal of Korean Pharmaceutical Sciences
2004 Volume.34 No. 6 p.477 ~ p.482
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Prevention of Postsurgical Adhesions with a Mixed Gel of Sodium Carboxymethyl Cellulose and Gellan Gum in the Rat
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권윤환/Kwon YH
이시범/이정권/박용덕/박정숙/황성주/Lee SB/Lee JG/Park YD/Park JS/Hwang SJ
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Abstract
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The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomy. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomy. The animals (60 female Sprague-Dawley rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4, 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4, 8, and 12 weeks. The mean adhesion scores were 0.75, 1.25, and 1.38 at 4, 8, and 12 weeks in the gel-treated group, respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomy model without affecting the healing of operation wound and other complications. Therefore, the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.
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KEYWORD
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Antiadhesion, Sodium carboxymethyl cellulose, Gellan gum, Laminectomy
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